MoCRA 2026 facility registration & adverse-event reporting deadlines hit hard
Effective Dec 2026; FDA fines up to $10K/day per facility
MoCRA-ready facility & responsible-person registry, adverse-event workflow, FDA submission XML export
AssayCore Beauty addresses the unique needs of cosmetics and personal care product laboratories. At its core is a formulation engine connected to 25,000+ INCI ingredients from the CosIng EU database, with full EU 1223/2009 Annexes II-VI compliance (banned substances, restrictions, colorants, preservatives, UV filters). The stability module supports 5 study types with Arrhenius and Q10 calculations. CPSR and PIF generation, CPNP notification XML export, and ISO 22716 GMP checklists complete the regulatory suite.
Compliance & Standards
Complete feature set covering every stage of your laboratory workflow.
Concrete laboratory pain — quantified — and how AssayCore Cosmetics addresses each.
MoCRA-ready facility & responsible-person registry, adverse-event workflow, FDA submission XML export
1,020+ INCI entries pre-loaded with CosIng-linked allergen / restriction flags
ISO 22716 stability engine with t90, Arrhenius equivalence, Q10 factor, automatic delta thresholds
Auto-flag rule per leave-on (0.001%) / rinse-off (0.01%) thresholds before label is locked
CPSR + PIF generator with EU/UK/ASEAN profiles and tracked-change history
ISO 16128 calculator scores % natural / natural-origin per ingredient with audit trail
Bundled CPU-only inference. Open datasets, transparent metrics, lab-tunable thresholds.
| Model | Task | Dataset | Metric | Latency | Status |
|---|---|---|---|---|---|
| cosmetics.toxicity_scorer | Score ingredient toxicity from molecular structure | Tox21 (HF: scikit-fingerprints/tox21, 8K compounds, public) | Avg AUC 0.81 across 12 assays | 35 ms (CPU) | Production |
| cosmetics.solubility_predictor | Predict water solubility (logS) from SMILES | MoleculeNet ESOL (1.1K, MIT) | R² 0.85, RMSE 0.62 | 18 ms (CPU) | Production |
| cosmetics.lipophilicity_predictor | Predict logP for skin-penetration estimation | MoleculeNet Lipophilicity (4.2K) | R² 0.80, MAE 0.48 | 20 ms (CPU) | Production |
| cosmetics.allergen_detector | Flag EU 26 fragrance allergens above thresholds | ref_eu26_allergen + EU 1223/2009 Annex III | Recall 1.00 / Precision 0.96 | 8 ms (CPU) | Production |
| cosmetics.ghs_classifier | Predict GHS H-codes from SMILES / ingredient name | ToxCast (8.6K, 617 assays, EPA public) | F1 0.78 multi-label | 40 ms (CPU) | Production |
| cosmetics.inci_safety_scorer | Composite safety score (0-100) per INCI | CIED + Tox21 + ToxCast ensemble | Spearman ρ 0.74 vs expert panel | 55 ms (CPU) | Production |
| cosmetics.stability_predictor | Predict 24-mo stability outcome from T₀ panel | Internal stability runs (synthetic, 5K studies) | Accuracy 0.82 | GPU only (preview) | GPU-only |
Calculations that actually run in AssayCore Cosmetics — every formula links to its source standard.
Δ = |x_T₆₀ − x_T₀| / x_T₀ISO 22716:2007 GMP Annex stability
t90 = ln(0.9) / −k_degICH Q1E; ASTM F1980
t_real = t_acc × exp(Ea / R × (1/T_real − 1/T_acc))ICH Q1A(R2); ASTM F1980
%NO = mass_NO / mass_total × 100ISO 16128-2:2017
flag = (c_allergen ≥ 0.001% leave-on) OR (c_allergen ≥ 0.01% rinse-off)EU 1223/2009 Annex III §67-92
log reduction = log10(N_0 / N_t)ISO 11930:2019 / USP <51>
Q10 = (k_(T+10) / k_T)ICH Q1E
Honest side-by-side. Where competitors lead we say so; where we lead, we show how.
| Competitor | Their offer | AssayCore Cosmetics |
|---|---|---|
| Coptis Lab | Strong INCI catalog but per-seat licensing, no native MoCRA module | MoCRA 2026 facility + adverse-event registry built-in, flat product pricing |
| COSMILE / Cosmile Pro | Consumer-facing INCI; no formulation engine, no stability calc | Full formulation versioning + ISO 22716 stability engine + CPSR/PIF generator |
| Formpak | Excellent fragrance compounding; weak EU CPNP / MoCRA workflows | CPNP XML export + MoCRA submission packets in one suite |
| TraceGains | Supplier compliance only, no formulation or stability | End-to-end: formulation → stability → CPSR/PIF → MoCRA/CPNP submission |
| LabVantage Cosmetics | $120-300K, 8-month deploy, GMP-focused but weak ISO 16128 natural-origin calc | $24.9-39.9K starter / $99K pro, 21-day deploy, ISO 16128 calculator out-of-box |
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